La Serie Mundial de 1928 fue disputada entre Saint Louis Cardinals y New York Yankees.
[1][2][3] Los New York Yankees resultaron ganadores al vencer en la serie por 4 partidos a 0.
LG: Waite Hoyt (1–0) LP: Bill Sherdel (0–1) HRs: STL – Jim Bottomley (1) NYY – Bob Meusel (1) LG: George Pipgras (1–0) LP: Grover Cleveland Alexander (0–1) HRs: NYY – Lou Gehrig (1) LG: Tom Zachary (1–0) LP: Jesse Haines (0–1) HRs: NYY – Lou Gehrig 2 (3) LG: Waite Hoyt (2–0) LP: Bill Sherdel (0–2) HRs: NYY – Babe Ruth 3 (3), Lou Gehrig (4), Cedric Durst (1)